盐酸丙帕他莫和哌替啶用于肾绞痛的比较研究

Comparison between Propacetamol Hydrochloride and Pethidine inTreating Acute Renal Colic

目的观察并比较盐酸丙帕他莫和哌替啶治疗肾绞痛的疗效及安全性。方法140名肾绞痛患者随机分为观察组和对照组各70例,观察组采用盐酸丙帕他莫2 g溶于100 ml生理盐水于15min静脉滴注,同时肌肉注射生理盐水1 ml;对照组采用哌替啶50 mg肌肉注射,同时静脉滴注100ml生理盐水15min。观察比较给药后1小时内两组的镇痛效果及不良反应。结果两组的镇痛效果无明显差异(P>0.05)但不良反应比较有显著性意义(P<0.01)。结论盐酸丙帕他莫与哌替啶用于肾绞痛疗效相似,但不良反应少,值得临床推广。

Objective To compare the effiicacy and safety of the propacetamol hydrochloride injecction and pethidine in the treatment of acute renal colic. Methods 140 patients with acute renal colic were randomized into two groups： the study group treated with 2g propacetamol inlOOml normal saline intravenously and 1.Oml normal saline intramuscularly ,the control group treated with lOOml normal saline intravvenously and 50mg pethidine intramuscularly. The intensity change of renal colic and adverse reactions were desc beginning of propacetamol infusion. Results There was no ohvious difference between the ribed during lh form the two groups on moderating renal colic （P〉0.05）.The incidence of side effects form Propacetamol HCL was less Pethidine HCL （P〈0.01）. Conclusion Intravenous Propacetamol and Intramuscular Pethidine HCL had the similar efficacy in treating acute renal colic. Since Propacetmol had less adverse reactions,it will more applicated as analgesic in the future.