摘要
采用ＲＴ－ｎＰＣＲ和合成肽包被的ＥＬＩＳＡ法对ＨＧＶ感染者进行随访研究和动态观察。２／１４ＨＧＶＲＮＡ和抗ＨＧＶ均阳性者３年后阴转；３／５单项抗－ＨＧＶ阳性者３年后阴转；２／７单项ＨＧＶＲＮＡ阳性者３年后阴转。２６例检出ＨＧＶ感染指标的献血员３年随访时仅１例ＡＬＴ为１４２。６例ＨＧＶ感染者１年动态观察显示，４例受血者１年内抗ＨＧＶ阳转，但仅１例受血者受血后２周时出现一过性ＡＬＴ升高。该研究证实ＨＧＶ可以经血传播并在体内有长期携带的趋势。６例ＨＧＶ感染者的动态观察未见ＨＧＶＲＮＡ或抗－ＨＧＶ与ＡＬＴ有相关。提示ＨＧＶ对肝脏的致病性较弱或致病需要辅助因子存在。
Anti-HGV and HGV RNA were detected by ELISA and RT-nPCR in a 3-year follow-up study on HGV infection.Anti-HGV and/or HGV RNA were found in 19/26 of former plasma donors who infected HGV 3 years before,while only 1 of the group had an abnormal ALT level.Tendency of chronic HGV carrier was also confirmed by 1-year dynamic observation of HGV RNA,anti-HGV and ALT in 6 HGV infected blood recipients.The study did not confirmed the correlation of chronic hepatitis and HGV infection.
出处
《微生物学免疫学进展》
1998年第4期29-31,共3页
Progress In Microbiology and Immunology
