微管骨架的动态特性及其调控

DYNAMICS AND REGULATION OF MICRO TUBULE SYSTEM

微管骨架是细胞骨架系统的主要组成成员，大多数微管的一个显著特征便是具有能够不断解聚、聚合的动态特性，这是微管骨架完成诸多生理功能的重要保证。本文着重介绍了有关微管的动态模型及其体内、体外组装的不同特点，并进一步探讨了生物体在各层次、各水平上对细胞内微管行为的调控。

Microtubules (MTs),one of the primary components in cytoskeleton system,are present in virtually all eukaryotic cells. It is well known that they play the key role in many important cellular actions such as mitosis,intracellular vesicle transport,organization and positioning of membranous organelles, and determination of cell shape and motility. One of the most prominent features of MTs is their dynamics. This review mainly focuses on some aspects of MT dynamic models and its distinct organizing behaviors in vivo/vitro. Furthermore,in living cells the regulation from several different levels is discussed.