1Goldstein B, Giroir B, Randolph A, et al. International pediatric sepsis consensus conference : Definitions for sepsis and organ dysfunction in pediatrics[ J]. Pediatr Crit Care Med,2005,6( 1 ) :2 -8.
2Akira S, Hasino K. Myeloid differentiation factor 88 - dependent and - independent pathways in toll - like receptor signaling [ J ]. J Infect Dis, 2003,187 ( suppl 2 ) :356 - 363.
4Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008[ J]. Crit Care Meal,2008,36( 1 ) :296 -327.
5Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock [ J ]. Crit Care Med, 2006, 34 ( 6 ) : 1589 - 1596.
6Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained:A potential risk factor for hospital mortality [ J]. Antimicrob Agents Chemother,2005,49 (9) :3640 - 3645.
7Kollef MH. Inadequate antimicrobial treatment: An important determinant of outcome for hospitalized patients [ J ]. Clin Infect Dis, 2000,31 (suppl 4) :131 - 138.
8El - Nawawy A, El - Kinany H, Hamdy El - Sayed M, et al. Intravenous polyclonal immunoglobulin administration to sepsis syndrome patients:A prospective study in a pediatric intensive care unit[ J]. J Trop Pediatr, 2005,51 (5) :271 - 278.
9Gao F, Melody T, Daniels DF, et al. The impact of compliance with 6 - hour and 24 - hour sepsis bundles on hospital mortality in patients with severe sepsis : A prospective observational study [ J ]. Crit Care, 2005, 9(6) :764 -770.
5Petersen B, Ramackers W, Tiede A, et al. Pigs transgenic for human thrombomodulin have elevated production of activated protein C [ J ]. Xenotransplantation ,2009,16 ( 6 ) :486 - 495.
6Tran S, Dahlback B. Novel APC - cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S[ J]. Thromb Haemost,2010,8( 1 ) :129 - 136.
7Gale AJ,Cramer TJ, Rozenshteyn D,et al. Detailed mechanisms of the inactivation of factor Ⅷα by activated protein C in the presence of its cofactors,protein S and factor V[J]. J Biol Chem,2008,283 (24) : 16355 - 16362.
8Messaris E, Betrosian AP, Memos N ,et al. Administration of human protein C improves survival in an experimental model of sepsis [ J ]. Crit Care Med,2010,38 ( 1 ) :209 -216.
9Gupta A, Gerlitz B, Richardson MA, et al. Distinct functions of activated protein C differentially attenuate acute kidney injury [ J ]. J Am Soc Nephrol,2009,20 (2) :267 - 277.
10Nagai M,Teran S, Yilmaz G, et al. Roles of inflammation and the activated protein C pathway in the brain edema associated with cerebral venous sinus thrombosis[ J]. Stroke ,2010,41 ( 1 ) : 147 - 152.
