胺碘酮抢救心肺复苏中持续性恶性室性心律失常的应用

Effect of Amiodarone for the Treatment of Malignant Ventricular Arrhythmia During Cardiopulmonary Resuscitation

【目的】观察胺碘酮对心肺复苏过程中恶性室性心律失常的疗效。【方法】收集本院心肺复苏过程中出现的恶性室性心律失常患者66例，分别给予胺碘酮（n=38）和利多卡因（n=28）治疗，记录心律失常发生情况并判定疗效。【结果】胺碘酮治疗组显效20例（52．6％），有效10例（26．3％），无效8例（21．1％），总有效率78．9％。利多卡因组显效7例（18．4％），有效8例（28．6％），无效13例（46．4％），总有效率53．6％。两组有效率比较差异有显著性（P〈0．05）。【结论】胺碘酮治疗心肺复苏过程中恶性室性心律失常有良好的临床疗效。

[Objective]To observe the clinical effect of amiodarone on malignant ventricular arrhythmia during cardiopulmonary resuscitation. [Methods] Sixty six cases with malignant ventricular arrhythmia were divided into two groups including amiodarone group（ n = 38） and lidocaine group（ n = 28）. The incidence of arrhythmia was recorded and the efficacy was analyzed. [Results] The rates of excellent, good and invalid in amiodarone group were 52.6%, 26.3% and 21. 1%, respectively, and the total effective rate was 78.9%. The rates of excellent, good and invalid in lidocaine group were 18.4%, 28.6% and 46.4% respectively, and the total effective rate was 53. 6%. There was significant difference in the total effective rate between two groups（ P 〈0.05）. [Conclusion] Amiodarone relatively has a good curative effect on the treatment of malignant ventricular arrhythmia during cardiopulmonary resuscitation, and it should be recommended as the first choice for the treatment.