白芍总甙治疗结缔组织病并发胆汁淤积性肝硬化疗效观察

Therapeutic Efficacy of Total Glucosides of Paenoy Treatment on Connective Tissue Disease with Biliary Liver Cirrhosis

目的评价白芍总甙(TGP)联合天晴甘平治疗结缔组织病并发胆汁淤积性肝硬化(PBC)的有效性,以熊去氧胆酸(UDCA)为对照。方法选择PBC患者28例,分为TGP组和UDCA组,分别予以TGP+天晴甘平和UDCA+天晴甘平治疗。于治疗前和治疗后1、3个月分别测定生化指标。结果治疗后两组患者TBil、ACT、AST、GGT、ALP均较治疗前明显降低(均P<0.05),TGP组和UDCA组在肝酶改变上无明显差异(P>0.05),在胆红素下降方面UDCA起效较TGP快(P<0.05)。两组副作用均轻微。结论白芍总甙可用于治疗PBC。

Objective To evaluate the effectiveness of total glucosides of paenoy （TGP） used with compound glyeyrrhizin in treatment of connective tissue disease with biliary liver cirrhosis （ PBC ）, using ursodeoxyeholic acid （UDCA） in combination in the treatment as the control. Methods Twenty-eight PBC patients were divided into TGP group and UDCA groups, treated by TGP ＋ compound glycyrrhizin and UDCA ＋ compound glyeyrrhizin respectively. Biochemical parameters were determined before treatment and 1 month and 3 months after treatment. Results TBil, ALT, AST, GGT and ALP were seen improved after treatment in both 2 groups （P 〈 0.05 ）, there was no significant difference in liver enzymes change between TGP and UDCA group（P 〉0.05 ）, and bilirubin in UCDA group decline faster than TGP （P 〈 0.05 ）. Side-effects in two groups were minor. Conclusion TGP can be used for the treatment of PBC.