红霉素在小儿哮喘急性发作中的应用

Erythromycin in children with acute attack of asthma

目的：观察红霉素治疗小儿哮喘急性发作的疗效。方法：选择2004年10月2006年12月在湖南省儿童医院呼吸免疫科住院确诊的哮喘急性发作患儿80例，随机分为两组，两组病例均给予青霉素抗感染、静脉用琥珀酸氢化考的松、氨茶碱，雾化吸入万托林、吸氧、翻身拍背吸痰等对症支持治疗。治疗组40例在常规治疗基础上加用红霉素100mg／（kg·次）加入葡萄糖液中静脉滴入，浓度不超过0．1％，每日2次，连用3天。结果：治疗组在缓解喘息症状、缩短哮鸣音持续时间、缩短住院时间方面均明显优于对照组。结论：哮喘急性发作是儿科急症之一，快速缓解哮喘急性发作是成功的关键。红霉素具有一定的抗气道非特异性炎症作用，还可抑制黏液分泌，抑制茶碱清除率，延长类固醇排泄时间，刺激肾上腺素的分泌等可协同其他药物快速缓解哮喘急性发作。

Goal： The observation erythromycin treats the young child asthma acute outbreak the curative effect. The method chooses in October, 2004 2006 year in December in the Hunan Province pediatric hospital breath immunity branch in hospital diagnosis asthma acute outbreak trouble 80 examples, divides into two groups stochastically, two groups of case of illness give the penicillin anti - infection, the vein the pine, the aminophylline which tests with the succinic acid hydrogenation, atomization inspiration ten thousand Tolin, attracts the oxygen, the turning over pats the back to attract the phlegm and so on the just right for the illness support treatment. The treatment group 40 examples add in the conventional treatment foundation with erythromycin 100rag/（ the kg ~ time） join the glu- cose fluid median vein to drip into, the density does not surpass 0.1%, daily 2 times, is used together 3 day. The result treatment group in the alleviation respite symptom, the reduction heavy breathing calls the sound duration, the reduction in hospital time aspect obviously surpasses the control group. The conclusion asthma acute outbreak is one of department of pediatrics acute diseases, alleviates the asthma acute outbreak is the successful key fast. The erythromycin has certain anti - gas channel non - specificity inflammation function, but also may suppress the mucus secretion, the suppression theine percentage clearance, the extension steroid excretion time, the stimulation adrenalin secretion and so on may coordinate other medicine fast alleviation asthma acute outbreak.