摘要
目的:观察奥沙利铂(L—OPH)联合氟尿嘧啶(5-FU)及亚叶酸钙(LV)治疗术后胃癌的疗效和不良反应。方法:26例胃癌术后患者,采用奥沙利铂(L—OPH)联合氟尿嘧啶(5-FU)及亚叶酸钙(LV)方案治疗,每月重复1次,治疗3个周期后评价疗效。结果:26例患者中,完全缓解3例(11.5%),部分缓解18例(69.2%),近期有效率80.8%。主要不良反应为恶心、乏力、感觉神经毒性和腹泻,无化疗相关死亡。结论:奥沙利铂(L—OPH)联合氟尿嘧啶(5-FU)及亚叶酸钙(LV)方案治疗胃癌疗效显著,安全性高,不良反应经处理后均可耐受,无严重不良反应发生,可作为一种供选择方案。
Goal: After observes Austria Sha Libo the (L - OPH) union fluorine uracil (5 - FU) and the Asi- an folic acid calcium (LV) iatrotechnics the stomach cancer curative effect and responded not good. Method: 26 example stomach cancer technique future trouble, uses Austria Sha Libo the (L -OPH) union fluorine uracil (5 - FU) and the Asian folic acid calcium (LV) plan treatment, each month duplicates 1 time, after treats for 3 cycles to appraise the curative effect. Finally: In 26 example patients, alleviates 3 examples completely (11.5%), the part alleviates 18 examples (69.2%), in the near future effectiveness 80.8%. Mainly not good responded for disgusting, asthenia, sensory nerve toxicity and diarrhea, does not have the chemotherapy correlation death. Conclu- sion: Austria Sha Libo the (L -OPH) union fluorine uracil (5 -FU) and the Asian folic acid calcium (LV) plan treats the stomach cancer curative effect to be remarkable, the security is high, responded not good may endure after processing, not serious responds the occurrence not good, may take one kind supplies the choice plan.
关键词
奥沙利铂
氟尿嘧啶
亚叶酸钙
胃癌
联合化疗
Oxaliplatin
fluorouracil
Leucovorin
gastric cancer
combination chemotherapy