期刊文献+

急性淋巴细胞白血病靶向基因治疗的研究进展 被引量:9

急性淋巴细胞白血病靶向基因治疗的研究进展
下载PDF
导出
摘要 急性淋巴细胞白血病具有恶性程度高、复发率高、多重耐药、预后差等特点,其治疗存在较大困难。化疗为其治疗的主要手段,不同化疗方案与预后治疗效果有关。靶向基因治疗在化疗过程中取得明显效果,现将近年来靶向基因治疗急性淋巴细胞白血病的研究进展综述如下。 Acute lymphoblastic leukemia with a high degree of malignancy,recurrence rate,multi-drug resistance,poor prognosis features,there is a greater diffi culty in its treatment.Chemotherapy for their primary means of treatment,different treatment regimen and prognosis related.Targeted gene therapy in the course of chemotherapy has achieved remarkable results,now in recent years,targeted gene therapy of acute lymphoblastic leukemia research are summarized below.
作者 张颜 何明生
出处 《当代医学》 2010年第2期35-36,47,共3页 Contemporary Medicine
关键词 急性淋巴细胞白血病 靶向基因 治疗 Acute lymphoblastic leukemia Targeted gene Therapy
  • 相关文献

参考文献19

  • 1Dearden CE,Matutes E,Cazin B,et al.High remission ratein T2cellprolymphocytic leukemia with CAMPATH21H[J].Blood,2001,98(6):1721.
  • 2Tibes R,Keating MJ,Ferrajoli A,et aI.Activity of alemtuzumab in patients with CD52-positive acute leukemia[J].Cancer,2006,106(12):2645-2651.
  • 3Heinrich MC,Griffith DJ,Druker BJ,et al.Inhibition of c2kit receptortyrosine kinase activity by ST1571,a selective tyrosine kinase inhibitor[J].Blood,2000,96(3):925.
  • 4Mullighan CG,Williams RT,Downing JR,et al.Failure of CDKN2A/B(INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by 8CR-ABL[J].Genes Dev,2008,22(11):1411-1415.
  • 5Ploner C,Rainer J,Niederegger H,et al.The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia[J].Leukemia,2008,22(2):370-377.
  • 6Stubbs MC,Armstrong SA,et al.FLT3 as a therapeutic target in childhood acute leukemia[J].Curr Drug Targets,2007,8(6):703-714.
  • 7Reindl C,Quentmeier H,Petropoulos K,et al.CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes[J].Clin Cancer Res,2009,15(7):2238-2247.
  • 8王娜,赵勇.LMO2与T细胞白血病[J].细胞生物学杂志,2005,27(3):253-256. 被引量:4
  • 9Van Vlierberghe P,Beverloo HB,Buijs-Gladdines J,et al.Monoalletic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia[J].Leukemia,2008,22(7):1434-1437.
  • 10Ryan DP,Duncan JL,Lee C,et al.Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12[J].Proteins,2008,70(4):1461-1474.

二级参考文献19

  • 1Yamada Y et al. Oncogene, 2002, 21:1309.
  • 2McCormack MP et al. N Engl J Med, 2004, 350:913.
  • 3Rabbitts TH. Genes Dev, 1998, 12:2651.
  • 4Grutz GG et al. EMBO J, 1998, 17:4594.
  • 5Fischer A et al. Nat Rev Immunol, 2002, 2:615.
  • 6Hacein-Bey-Abina Set al. Science, 2003, 302:415.
  • 7Stone BD, N Engl J Med, 2004, 350:2526.
  • 8Rabbitts TH et al. Cancer Res, 1999, 59: 1794s.
  • 9Davenport J et al. Leukemia, 2000, 14:1986.
  • 10Kadrmas JL et al. Nat Rev Mol Cell Biol, 2004, 5:920.

共引文献3

同被引文献90

引证文献9

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部