纤维蛋白原对急性白血病患者脓毒症严重程度的评估作用研究

Evaluation Effect of Fibrinogen on the Severity of Sepsis in Acute Leukemia Patients

目的研究纤维蛋白原(FIB)对急性白血病患者发生重症脓毒症危险性的预测评估作用。方法回顾性分析比较19例重症脓毒症和48例非重症急性白血病脓毒症患者血浆的FIB和血清C反应蛋白(CRP)。结果在第0、3、4d重症脓毒症患者血浆FIB明显高于非重症组(P<0.05),而两组间血清CRP在各个时间点均没有显著差异(P>0.05)。FIB与CRP在所有时间点均有显著相关性(P<0.01)。结论血浆FIB浓度可以预测中性粒细胞缺乏性发热的急性白血病患者发生重症脓毒症的危险性。

Objective To evaluate the prognostic effect of fibrinogen（FIB） on the severity of sepsis in acute leukemia patients. Methods Using the retrospective analysis method to compare plasma FIB and serum C-reactive protein （CRP） between 19 acute leukemia patients with severe sepsis and 48 with non-severe sepsis. Results Plasma FIB on the 0,3rd and 4th day in severe sepsis patients was significantly higher than that in the non-severe group（P0.05）. However,there was no significant difference in the serum CRP between these two groups in each time points（P0.05）. FIB and CRP had significant correlation in all time points（P0.01）.Conclusion Plasma FIB could forecast the tendency to severe sepsis in acute leukemia patients with neutropenic fever.