急性缺氧状态下苦菜总黄酮对心脑的保护作用

Protective action of bitter vegetable flavoniods （BVF） on hearts and brains under the condition of acute hypoxia in mice

目的探讨急性缺氧状态下苦菜总黄酮对心、脑的保护作用。方法利用小鼠急性缺氧装置，测定小鼠的耐缺氧能力，并测定小鼠心脑超氧化物歧化酶（SOD）、丙二醛（MDA）和一氧化氮（NO）的含量。结果苦菜总黄酮可使小鼠的耐缺氧作用明显加强，其作用具有剂量依赖性。苦菜总黄酮可使心脑SOD的含量呈剂量依赖性增加，而MDA的含量随着剂量增加而减少。随着苦菜总黄酮剂量的增加，心肌组织中NO的含量减少越明显；低、中和高剂量均明显降低脑中NO的含量。结论苦菜总黄酮在急性缺氧状态下对心、脑具有保护作用，其作用机制可能与提高SOD活性，降低MDA、NO含量有关。

Objective To study the protective effect of bitter vegetable flavoniods （BVF） on hearts and brains under the condition of the acute hypoxia. Methods On the device of mice acute hypoxia, ability of tolerancing hypoxia of mice was investigated, and superox/de dismutase（SOD ）, malondialdehyde（MDA） and nitric oxide（NO） contents in hearts and brains were measured. Results BVF strengthened the resisting hypoxia capability in mice significantly, and the effect showed does-dependent. BVF increased SOD levels in hearts and brains in does-dependent. BVF decreased MDA contents in hearts and brains. For NO level in hearts, BVF decreased it by does-dependently. BVF could notablely reduce NO level in brains in any does. Conclusion BVF has a notable protection on brains and hearts under the condition of acute hypoxia in mice, and the mechanism probably relate to decrease remarkably the content of MDA and NO, and increase the activity of SOD on hearts and brains under the condition of the acute hypoxia in the mice.