1Antoniou KM,Pataka A,Bouros D,et al.Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis[J].Pulm Pharmacol Ther,2007,20(5):453 -461.
2American,Thoracic,Society.ATS/ERS international consensus Classification of idiopathic interstitical Pneumonias[J].Am J Respir Crit Care Med.,2002,15;165(2):277-304.
3AM Cantin R,Boileau and R Begin.Increased procollagen Ⅲ aminoterminal peptide-related antigens and fibroblast growth signals in the lungs of patients with idiopathic pulmonary fibrosis[J].Am Rev Respir Dis,1988,137(3):572-8.
4A Clement,K Chadelat,J Masliah,et al.A controlled study of oxygen metabolite release by alveolar macrophages from children with interstitial lung disease[J].Am Rev Respir Dis,1987,136(6):1424-8.
5J Strausz,J Muller-Quernheim,H Steppling,et al.Oxygen radical production by alveolar inflammatory cells in idiopathic pulmonary fibrosis[J].Am Rev Respir Dis,1990,141(1):124-8.
6Waiters DM,Cho HY,Kleeberger SR.Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis:apetential role for nrl2[J].Antioxid Redox Signal,2008,10(2):321 -332.
7Liu R,Ahmed KM,Nantajit D,et al.Therapeutic effects of alpha-lipoic acid on bleomycin-induced pulmonary fibrosisin rots[J].Int J Mol Med,2007,19 (6):865 -873.
8Lisa G.Wood,Dominic A.et al.Oxidative Stress in Cystic Fibrosis:Dietary and Metabolic Factors.J.Am.CoIl.Nutr,2001,20:157 - 165.
2Fujisawa T. Role of oxygen radicals on bronchial asthma. Curr Drug Targets Inflamm Allergy, 2005,4 : 505-509.
3Andreadis AA, Hazen SL, Comhair SA, et al. Oxidative and nitrosative events in asthma. Free Radic Biol Med, 2003,35 : 213- 225.
4Derjuga A, Gourley TS, Holm TM, et al. Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol,2004,24:3286-3294.
5Igarashi K,Sun J. The heme-bachl pathway in the regulation of oxidative stress response and erythroid differentiation. Antioxid Redox Signal, 2006,8 : 107-118.
6Shen G, Hebbar V, Nair S, et al. Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem, 2004,279 : 23052-23060.
7McMahon M, Thomas N, Itoh K, et al. Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redoxinsensitive Neh6 degron. J Biol Chem, 2004,279:31556-31567.
8Nioi P, Nguyen T,Sherratt P J, et al. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Mol Cell Biol,2005,25 : 10895-10906.
9Dhakshinamoorthy S,Jain AK,Bloom DA,et al. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element ( ARE )-mediated NAD ( P ) H: quinone oxidoreductase 1 gene expression and induction in response to antioxidants. J Biol Chem,2005,280 :16891-16900.
10Kobayashi M, Itoh K, Suzuki T, et al. Identification of the interactive interface and phylogenic conservation of the Nrf2- Keap1 system. Genes Cells, 2002,7 : 807-820.