CD44v与白血病的关系

Relationship between CD44v and leukemia

CD44分子是一种广泛的细胞表面跨膜糖蛋白,可通过选择性表达不同的外显子形成多种同源异构体,即标准型（CD44s）与变异型（CD44v）.CD44分子高表达于所有急性髓系白血病（AML）亚型原始细胞上,应用CD44单克隆抗体能够不同程度地抑制多种髓系白血病细胞株的增殖并诱导细胞分化或凋亡.就CD44v和白血病关系的研究进展进行综述.

CD44 adhesion molecule is a cell surface transmembrane glycoprotein.It displays many varinat isoforms generated by alternative splicing of exons, including CD44s. and CD44v. It has been reported that CD44 adhesion molecule is strongly expressed on the surface of leukemic blasts in all acute myeloid leukemia subtypes.It has been found through in vitro study that CD44 monoclonal antibodies can inhibit proliferation of all acute myeloid leukemia cell lines and induce terminal differentiate or apoptosis of some cell lines to diverse extent. In this review the relationship between CD44v, and leukemia was analysed.