益气活血通络法对特发性肺纤维化患者生存质量的影响

Influence of therapy of supplementing qi,activating blood circulation and free the collateral vessels on life quality in patients with IPF

目的探讨益气活血通络法对特发性肺间质纤维化(IPF)气虚血瘀证患者生存质量的改善作用。方法符合中西医诊断标准的IPF患者30例,采用自身前后对照的方法,给予益气活血通络汤口服,每日1剂,每服200 mL,每日服2次。3个月为1疗程,观察2个疗程。以呼吸疾病问卷(SGRQ)作为测评工具,观察患者生存质量的改善情况。结果治疗6个月时SGRQ中呼吸症状评分、活动受限评分、总分积分均有所降低,与治疗前相比有显著性差异(P<0.05);疾病影响评分也有所降低,但与治疗前相比未见显著性差异(P>0.05)。结论益气活血通络法对改善IPF气虚血瘀证患者生存质量具有显著意义。

Objective To discuss the effect of the therapy of supplementing qi,activating blood circulation and free the collateral vessels on life quality in patients with the syndrome of qi deficiency and blood stasis of idiopathic pulmonary fibrosis（IPF）.Method The patients（n=30） accorded with the diagnostic standard of Chinese and Western medicine were chosen and given Yiqihuoxuetongluo Decoction orally,one decoction and twice a day（200 mL once）.One therapeutic course was 3 months and the patients were observed for 2 courses.St.George＇s respiratory-disease questionnaire（SGRQ） was taken as an examination tool to observe the improvement of life quality in the patients.Result After th treatment for 6 months the scores of respiratory symptoms and activity limitation,and the total integral decreased in SGRQ,and there was a difference before and after the treatment（P〈0.05）.The score of disease impact decreased a little and there was a difference before and after the treatment（P〉0.05）. Conclusion The therapy of supplementing qi,activating blood circulation and free the collateral vessels is significant to the life quality of the patients with the syndrome of qi deficiency and blood stasis of IPF.