循环内皮细胞与肿瘤血管生成的关系

Relationship between circulating endothelial cells and tumor angiogenesis

循环内皮细胞（CEC）是指外周血中测得的血管内皮细胞。其在健康人外周血中数量极少，而在动脉粥样硬化、糖尿病、红斑狼疮等疾病中明显增加，被认为是判断血管内皮细胞损伤情况特异而直接的指标。目前临床科研上常用流式细胞术检测计数和免疫磁珠分离法对CEC进行检测和计数。已有多项研究结果证实，CEC与肿瘤关系密切，现就对CEC的来源、检测、与肿瘤血管生成的关系以及在肿瘤预后监测的意义等进行综述。

Circulating endothelial cells （CEC） are endothelial cells which are detected in the peripheral blood. There are very few CEC in healthy adults while the number is obviously increasing in patients with arthrosclerosis, diabetes mellitus, lupus erythematosus, et al. Nowadays, flow cytometry analysis and immunomagnetic isolation for CEC are employed successfully in clinic and scientific research. Several research findings have confirmed that there is intimate relation between CEC and tumorigenesis. Because of the important role in angiogenesis and tumor growth, CEC would be a perspective tumor marker in antiangiogenesis and would also predict the chemotherapy efficacy.