严重急性呼吸综合征康复期患者肺功能五年动态观察

Pulmonary Function of Convalescent Patients with SARS:A five-year successive observation

目的通过观察严重急性呼吸综合征(SARS)患者康复期肺功能的变化,了解SARS遗留肺功能损害者的远期转归。方法对46例观察对象,按出院后肺弥散功能正常与异常分组,进行5年7次的定期随访,观察两组人群肺功能的变化趋势。结果正常组5年随访肺功能变化无统计学意义(P>0.05),而异常组5年中肺弥散功能值占预计值百分比(DLco%)、肺总量占预计值百分比(TLC%)、残气量占预计值百分比(RV%)3个参数差异有统计学意义(P<0.05),且呈上升趋势。结论SARS引起的肺功能损害与肺纤维化损害不同,大部分可恢复正常。

Objective To investigate the remote outcome of pulmonary dysfunction left in patients with serious acute respiratory syndrome （SARS） through observing the functional changes of convalescent SARS patients. Methods Totally 46 SARS patients were divided as normal and abnormal groups according to their pulmonary diffusion function. Seven - time follow ^- ups were conducted in five years to observe the changing trends of pulmonary function for the patients in the two groups. Results During the follow - ups in the five years, in normal group no statistically significant changes were found （ P 〉 0. 05 ） ; but in abnormal group, there were significantly increasing trends in the three parameters of diffusing capacity of the lung for carbon mon- oxide predicted percent （DLco%）, total lung capacity predicted percent （TLC%） and residual volume predicted percent （ RV% ） （ P 〈 0. 05 ）. Conclusion The damages of pulmonary function induced by SARS were different from that in pulmonary fibrosis, most of which could recover gradually.