细胞因子的基因多态性与幽门螺杆菌感染及其继发性疾病的关系

Interleukin Gene Polymorphisms and Helicobacter Pylori Infection in Human

幽门螺杆菌(Helicobacter pylori,Hp)感染与胃肠道疾病中的慢性胃炎、消化性溃疡、胃癌等疾病的发生和发展密切相关。但是不同的人在Hp感染后临床表现差异很大,有的患者表现为长期无症状携带者,有的则在一段时间后发展为胃炎或胃癌。感染Hp后患者临床表现间的差异除了与其本身对疾病易感性有关外,细胞因子在Hp感染过程中发挥着重要作用。近年来有关细胞因子基因多态性与Hp及其继发性疾病的研究较多,本文对近年来有关细胞因子基因多态性与Hp及其继发性疾病的研究做一综述。

Helieobaeter pylori （Hp） infection plays an important role in the development of gastritis, gastric ulcer, duodenal ulcer and gastric cancer. But the clinical manifestations of different individuals infected by Hp vary widely, some are long -term asymptomatie carriers, others develop gastritis or gastric cancer. The cell factors are important in the process of Hp infection. Nowadays, the relations between eytokines gene polymorphism and Hp infection are studied and reported. This paper reviews the recent studies of eytokine gene polymorphisms and Hp and its secondary diseases.