糖尿病并发短暂性脑缺血发作患者血脂及高敏C反应蛋白水平与预后的关系

Relationships between Serum Lipid,hs-CRP and Prognosis of Patients with Diabetes Mellitus Merger Transient Ischemic Attacks

目的探讨糖尿病并发短暂性脑缺血发作（TIA）患者血脂、血清高敏C反应蛋白（hs—CRP）与预后的关系。方法选择80例糖尿病并发TIA首次发作患者，对其随访1年，其中31例糖尿病并发2—4次TIA（B组），6例发生缺血性卒中（C组），余43例随访中未再发生TIA及缺血性卒中（A组）；另选择40例糖尿病无TIA者作为对照组。检测各组患者血脂及血清hs—CRP水平。结果A、B、C组患者血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）、hs—CRP水平均显著高于对照组，差异有统计学意义（P〈0．01）；B、C组患者血清TC、LDL—C、hs—CRP水平显著高于A组，差异有统计学意义（P〈0．05）；C组患者血清TC、LDL—C、hs—CRP水平又显著高于B组，差异有统计学意义（P〈0．05）。结论血脂及hs—CRP水平可作为判断糖尿病并发TIA患者预后的指标；血脂、血清hs—CRP水平升高，提示糖尿病并发TIA患者预后较差。

Objective To explore the relationship between levels of serum hpid, high sensitive C -reactive protein （ hs - CRP） and prognosis of patients with diabetes mellitus merger transient ischemic attacks （TIA）. Methods During 1 year follow- up period, to observe diabetes mellitus merger TIA first attacked 43 cases （A group） ; diabetes mellitus merger more than twice attacked 31 cases （B group） ; 6 cases developed ischemic stroke （C group） ; diabetes melhtus 40 cases, and none of patients with TIA as control group. Lipid and hs - CRP in serum was detected in 24 hours for 80 patients and 40 controls. Resuits Serum lipid and hs - CRP level of group A, B, C, were higher than control group （P 〈 0. 01 ） ; serum lipid and and - CRP level of patients in group B and C, were much higher than group A （P 〈 0.05） ; serum hpid and hs - CRP in serum of patients in group C, were much higher than group B （ P 〈 0. 05 ）. Conclusion Serum hpid and hs - CRP are useful index for diabetes mellitus merger TIA patients, and high seral level of serum hpid and hs - CRP may predicate relatively higher recurrence.