硫辛酸联合恩再适治疗化疗药物致周围神经病变的疗效观察

Clinical Observation to Combination Treatment of Lipoic Acid and Analgecine for Chemotherapy-induced Peripheral Neuropathy

目的观察硫辛酸联合恩再适治疗抗肿瘤药物所致周围神经病变的疗效。方法将43例恶性肿瘤化疗后周围神经病变患者,给予硫辛酸600 mg+恩再适7.2 U静脉滴注,1次/d,共2周。比较治疗前后患者临床症状和体征变化。结果治疗前后神经电生理检查,正中神经、腓总神经的神经传导速度(MCV)间差异均有统计学意义(P<0.05);治疗前患者视觉模拟评分(VAS)为(5.2±2.5)分,治疗后为(1.9±1.2)分,治疗前后比较差异有统计学意义(P<0.01);治疗后显效率为83.72%,总有效率为95.34%。结论硫辛酸与恩再适联用可显著改善恶性肿瘤化疗后的周围神经症状。

Objective To observe the clinical effect of Lipoic acid and Analgeeine on peripheral neuropathy induced by anticancer drugs. Methods Forty - three patients with chemotherapy - induced peripheral neuropathy were given lipoic acid （600 rag） with intravenous infusion of analgecine （7.2 U）, once a day, 2 weeks. The changes of clinical symptoms and signs were compared between pre - and post - treatment. Results There was significant difference in MCV of median nerve and common peroneal between pre - and post - treatment （ P 〈 0. 05 ）. The visual analogue scale （ VSA ） was （ 5.2 ± 2, 5 ） before treatment, and （ 1.9 ± 1.2） after treatment, the difference was significant （P 〈0. 01 ）. The posttreatment efficiency was 83.72%, total effective rate 95. 34%. Conclusion Lipoic acid combined with analgecine can improve effectively the peripheral nerve symptoms after chemotherapy of malignant tumors.