胃腺癌组织中67LR的蛋白表达及其意义

Protein expression of 67LR in the tissues of gastric adenocarcinoma and its significance

目的:探讨67LR蛋白在胃腺癌组织中的表达及其意义。方法:采用免疫组化SP法检测46例胃腺癌组织及其切端正常胃黏膜组织中67LR的蛋白表达。结果:正常胃黏膜组织及胃腺癌组织中67LR蛋白的阳性表达率分别为21.74%(10/46)和71.74%(33/46),2者相比,差异有显著性(P<0.01)。淋巴结转移组67LR蛋白的阳性表达率为92.00%(23/25),无淋巴结转移组其阳性表达率为66.67%(14/21),2组相比,差异有显著性(P<0.05)。结论:67LR蛋白的异常表达与胃腺癌的发生、发展及转移有关。

Objective： To investigate the protein expression of 67LR in the tissues of gastric adenocarcinoma and its significance.Methods： The protein expression of 67LR in the 46 cases of gastric adenocarcinoma and 46 cases of normal mucosa of gastric was detected respectively by the technology of immunohistochemistry SP.Results： The positive expression rate of 67LR protein in gastric adenocarcinoma and normal mucosa of gastric was 71.74%（33/46）and 21.74%（10/46） respectively.There was significant difference between normal mucosa tissue group and carcinoma tissue group（P〈0.01）.The positive expression rate of 67LR protein in gastric adenocarcinoma with lymph node metastasis group was higher than that with non-lymph node metastasis group.There was significant difference between two groups（P〈0.05）.Conclusion： It might indicate that the expression of 67LR protein could participate in the occurrence,development and metastasis of gastric adenocarcinoma.