睾丸鞘膜孤立性纤维性肿瘤1例及文献复习

Solitary Fibrous Tumor of Testis Sheath:A Clinic Opathologic Analysis of a Case and Review of Literature

目的：探讨睾丸鞘膜孤立性纤维性肿瘤的临床病理学特点、免疫组化特征及鉴别诊断。方法：对I例睾丸鞘膜孤立性纤维性肿瘤进行组织学观察,行MaxVision法免疫组化CD34、CD99、SMA、Desmin、actin、S-100、bcl-2、AE1/AE3染色及随访。结果：眼观：肿瘤呈结节状,结节直径为0.4~1.2 cm,切面灰白、实性、质韧。镜检：肿瘤由密集的胶原带构成,形成瘢痕疙瘩样的密集胶原束。梭形细胞位于胶原纤维之间呈束状排列,部分呈血管外皮瘤样结构。肿瘤细胞呈CD34及CD99弥漫性细胞质阳性,SMA、Desmin、actin、S-100、bcl-2、AE1/AE3均阴性。结论：睾丸鞘膜孤立性纤维性肿瘤罕见,应与该部位相似形态的病变和血管外皮瘤样的肿瘤相鉴别。

Objective：To explore the clinical pathological features,immunohistochemical characteristics and differential diagnosis of solitary fibrous tumor（SFT）of the testis sheath.Methods：A case of SFT of the testis sheath Was examined with light microscopy and immunohistochemistry,including CD34、CD99、SMA、Desmin、actin、S-100、bcl-2、AE1/AE3 with MaxVision method and literatures were reviewed.Results：The patient was a 23 year-old man with a tumor in the testis sheath for 4 years.Grossly.the tumor was nodular with diameter 0.4～1.2cm,scribed with grey white color on cut surface.Microscopically,the tumor was composed of dense band of collagen composition,forming dense keloid-like collagen bundle.Spindle cell is located between the collagen fiber bundles.Focal areas showed a haemangiopericytoma—like structure.Immunohistochemically,the tumor cells were positive for CD34 and CD99,but negative for SMA、Desmin、actin、S-100、bcl-2、AE1/AE3 protein.Conclusions：SFT is a very rare tumor,especially in testis sheath,and it should be differentiated from the tumors that have features similar to the shape of the lesion site,and hemangiopericytoma-like tumor.