Muller细胞在增殖前期糖尿病性视网膜病变中的作用

Evaluat the Muller Cells′ role in Retinal Neovascularization

目的：评价Muller细胞在增殖前期糖尿病性视网膜病变（DR）,视网膜无灌注区形成中的作用。方法：对181例（362眼）非增殖期、增殖前期DR病人进行了闪光视网膜电图（ERG）、局部ERG、12、32、40赫兹闪烁光ERG检查,计算纤维指数：闪光ERG的b波幅值/12赫兹闪烁光ERG幅值。结果：非增殖期DR的32、40赫兹闪烁光ERG b波幅值位于正常低限,闪光ERG的a波幅值中度降低,为（54±9.6）μv,b波幅值正常,12赫兹闪烁光ERG幅值明显降低,为（25.8±9.4）μv,纤维指数平均为9.3±1.4,增殖前期DR的所有视网膜电反应均中度下降,闪光ERG的b波幅值为（179±19）μv,12赫兹闪烁光ERG幅值等于（13.0±6.4）μv,纤维指数为10~16单位,平均：13.8±1.3,也就是说,有极显著增高（P〈0.001）。结论：纤维指数增高是视网膜缺血的共同特点,表明Muller细胞的代谢活性代偿性增高,证实其在视网膜无灌注区形成中起重要作用。

Objective：Evaluat the muller cells＇role in retinal nonperfusionMethods：Carrying on BF-ERG,local electroretinogram and 12,32,40Hz flicker ERG to 181（362 eyes） patient with NPDR,pre-PDR and PDR in the early stage,calculating fiber exponent： BF-ERG b-wave amplitude value/12Hz flicker ERG width value,Results：Propagate NPDR 32,40Hz flicker ERG b-wave width value to locate not normal low limit,BF-ERG a-wave width value to lower in the degree,equal to（54±9.6）uv.BF-ERG b-wave width value normal 12Hz flicker ERG width value significantly lower.for（25.8±9.4）uvfiber exponent equivalent9.3±1.4,all of retinal to pre-PDR are respond all medium degree descend.flicker ERG b-wave width value is（179±19）uv.12Hz flicker ERG width value equivalent to（13.0±6.4）uv.fiber exponent is 10~16 units,average：13.8±1.3.In other words,it is obvious improvement（P0.001）.Conclusions：Increased fiber exponent are the common characteristics of retinal neovascularization.indicate muller cell＇s metabolic activity compensatory increase,confirm muller cells play an important role in trigging of retinal NV.