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白细胞介素-18和白细胞介素-10在慢性丙型肝炎抗病毒治疗中的动态变化 被引量：7

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摘要 目的:观察血清细胞因子白细胞介素-18(IL-18)和白细胞介素-10(IL-10)在慢性丙型肝炎患者干扰素联合利巴韦林抗病毒治疗过程中的动态变化,探讨它们在慢性丙型肝炎发病中的作用及抗病毒治疗对它们水平的影响。方法:采用酶联免疫吸附法(ELISA)检测30例正常人、82例慢性丙型肝炎患者抗病毒治疗前、治疗4、8、12、24周血清中IL-18和IL-10的水平,同时检测肝功能和HCVRNA(定量PCR法)。结果:慢性丙型肝炎患者治疗前血清IL-18和IL-10的水平显著高于正常人(P<0.01),其值与丙氨酸氨基转移酶(ALT)活性呈显著正相关。抗病毒有效者,在治疗4个时间点血清IL-18和IL-10的水平均较治疗前显著下降(P<0.05);完全应答组较无应答组细胞因子水平治疗前后改变更显著。结论:细胞因子IL-18和IL-10与慢性丙型肝炎肝脏炎症活动和肝脏损害密切相关,干扰素能够调节机体的免疫状态而发挥抗病毒作用。
作者 应若素 陈志敏 刘惠媛 石裕明 龙英姿 陆勤 卢业成
机构地区 广州市第八人民医院
出处 《实用医学杂志》 CAS 北大核心 2010年第6期979-981,共3页 The Journal of Practical Medicine
基金 广州市医药卫生科技一般引导项目(编号:2008-YB-077)
关键词 肝炎 丙型 慢性 IL-18 IL-10 干扰素
分类号 R512.63 [医药卫生—内科学]
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参考文献10

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实用医学杂志
2010年 第6期

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