黄芪桃红汤对乳腺癌术后化疗患者细胞免疫功能的影响

Effect of radix astragali taohong decoction on cellular immune function in breast cancer patients with postoperative chemotherapy

目的观察黄芪桃红汤对乳腺癌术后化疗患者细胞免疫功能的影响。方法将乳腺癌术后患者80例随机分成2组,治疗组40例以CEF(环磷酰胺+表柔比星+氟尿嘧啶)方案化疗,同时口服中药黄芪桃红汤;对照组40例单纯CEF方案化疗,两组共治疗6个周期。治疗前后检测两组外周血T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)及自然杀伤细胞(NK细胞)。采用成组设计两独立样本t检验、Mann-Whitney秩和检验及配对t检验比较两组间细胞免疫功能指标的差异。结果治疗前两组各项细胞免疫指标之间差异无统计学意义(P>0.05);治疗结束后,治疗组CD3+和CD4+/CD8+细胞明显高于对照组(Z=-4.18P=0.00,Z=-2.14P=0.03),而两组CD4+、CD8+、NK细胞治疗前后的差值比较差异均无统计学意义(P>0.05);治疗组治疗后CD3+细胞明显高于治疗前(t=5.48,P=0.00),其余指标治疗前后比较差异均无统计学意义(P>0.05);对照组各项指标治疗前后比较差异均无统计学意义(P>0.05)。结论黄芪桃红汤能改善乳腺癌术后化疗患者的细胞免疫功能,其主要体现在能升高CD3+(总T细胞)和CD4+/CD8+指标,从而使机体更有效地发挥抗肿瘤效应。

Objective To observe the effect of radix astragali taohong decoction on cellular immune function in breast cancer patients with postoperative chemotherapy. Methods Eighty breast cancer patients who had received operation were randomly divided into two groups： a therapy group （n=40） treated with epirubicin plus fluorouracil （CEF） plus radix astragali taohong decoction, and a control group （n=40） treated with CEF only. The two groups both received 6 cycles of therapy. The T lymphocyte subsets such as CD3^＋ ,CD4^＋ ,CD8^＋ , CD4^＋/CD8^＋ , as well as natural killer （NK） ceils were detected before and after therapy in both groups. Paired t test, Mann-Whitney test and t test were applied for comparison of the cell immune function between the two groups. Results No significant difference in CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋ and NK ceils was found before therapy between the two groups （P〉0.05）. After therapy, CD3^＋ cell and CD4^＋/CD8^＋ cell in the therapy group were higher than in the control group（Z=-4.18 P=0.00,Z=-2.14 P=0.03）. The difference in CD4^＋ , CD8^＋ , and NK cell between pre-therapy and post-therapy was not statistically significant between the two groups（P〉0. 05）. In the therapy group CD3^＋ was significantly higher in post-therapy than in pre-therapy（t=5.48 , P= 0.00）. The other indexs were not statistically different between pre and post-therapy（P^0.05）. All indexes in the control group had no statistical difference between pre- and post-therapy （P〉0. 05）. Conclusion Radix astragali taohong decoction can improve the cellular immune [unction of patients with breast cancer, for it increases CD3^＋ （T-lymphocytes） and CD4^＋/CD8^＋ significantly, thus, motivating the body organisms to raise the ability of resistance to tumor.