羟丙基-β-环糊精对双苯氟嗪包合作用的热力学研究

A thermodynamic study on inclusion complexes of hydroxypropyl-β-cyclodextrin with dipfluzine

The inclusion complexes formation of dipfluzine(DF)with hydroxpropy-β-cyclodextrin(HP-β-CD)in aqueous solution was investigated by the phase-solubility method.With the increase of HP-β-CD concentration in aqueous sloutions,the solubility of DF increased linearly,which showed typical AL-type phase solubility diagram.The molar ratio of the DF-HP-β-CD complex was 1∶1.The effect of temperature on the reaction was studied through thermodynamics.The apparent stability constants of inclusion reation were determined.Thermodynamic parameters during the inclusion process were as follows: △rH=30.58 kJ·mol-1,△rS=158.8 J·mol-1·K-1,△rG<0.The complex process was endothermic and spontaneous.With the increase of temperature,the tendency of spontaneous reaction increased.

The inclusion complexes formation of dipfluzine （DF） with hydroxpropy -β-cyclodextrin （HP-β-CD） in aqueous solution wan investigated by the phase-solubility method. With the increase of HP-β-CD concentration in aqueous sloutions, the solubility of DF increased linearly,which showed typical AL-type phase solubility diagram. The molar ratin of the DF-HP-β-CD complex was 1：1 . The effect of temperature on the reaction was studied through thermodynamics. The apparent stability constants of inclusion reation were determined. Thermodynamic parameters during the inclusion process were as follows ： △t H = 30. 58 kJ . mol^-1 , △t S = 158.8 J. mol^-1 . K^-1 , △ G 〈 0. The complex process was endothermic and spontaneous. With the increase of temperature, the tendency of spontaneous reaction increased.