非小细胞肺癌患者生存3年以上的因素分析

Analysis of prognosis factors in non-small cell lung cancer patients surviving more than three years

目的研究非小细胞肺癌患者经综合治疗后3年以上长期生存的临床特点。方法197例非小细胞肺癌患者中，有28倒接受手术联合化疗；36例采用放疗联合化疗；75例接受手术联合放化疗；58例单用吉非替尼治疗。结果197病例中，超过3年以上（36～96个月）生存者共计32例，3年总生存率为16．2％。吸烟史（P=0．020）、KPS评分（P=0．000）、性格特征（P=0．012）、亲情关怀（P=0．010）、临床分期（P=0．001）、初治疗效（P=0．000）对3年生存率均有显著影响。而与性别（P=0．102）、年龄（P=0.065）、文化程度（P=0．590）、经济状况（P=0．055）、病理类型（P=0．453）、既往治疗方式（P=0．059）则无显著性关系。结论不吸烟、性格开朗、家庭亲情关怀好、临床分期早、KPS评分高、初治有效者是非小细胞肺癌患者3年以上生存的重要因素。其中早期诊断，规范非小细胞肺癌初次治疗尤为重要。

Objective To explore clinical characteristics of non-small cell lung cancer patients surviving more than 3 years. Method 197 patients with non-small cell lung cancer were retrospective analyzed. Results There were 32 patients （16. 2%） were survived more than 3 years. There were 6 factors influencing on lung-terra survival, including smoking history, KPS points, characteristics traits, family care, clinical stage and initial effect. Conclusion Smoking, characteristics traits, family care, clinical stage, general status and initial effect are important factors to impact on longterm survival for non-small cell lung cancer patients.