期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

对氨基苄醇的合成研究

Study on P-aminobenzyl Alcohol Synthesis
下载PDF
导出
摘要 以4-硝基苄醇为原料,分别采用Pd/C,Fe(Ⅲ)-MgO或Fe(Ⅲ)-水合肼为催化剂合成了对氨基苄醇。通过对比三种催化剂所得产物的收率和气相色谱检测的含量可知:以4-硝基苄醇合成对氨基苄醇时应选用Fe(Ⅲ)-水合肼为催化剂,其收率可达79.8%,气谱检测含量为98.7%。 P-aminobenzyl alcohol is synthetized from 4-nitrobenzyl alcohol with presence of Pd/c,Fe(Ⅲ)-MgO or Fe(Ⅲ)-hydrazine hydrate as catalyst.According to the yield rate and purity of product,we know that Fe(Ⅲ)-hydrazine hydrate is the best catalyst for P-aminobenzly alcohol synthesis from 4-nitrobenzyl alcohol.
作者 李方桥
机构地区 湖北三峡职业技术学院
出处 《化工设计通讯》 CAS 2010年第1期44-46,共3页 Chemical Engineering Design Communications
关键词 对氨基苄醇 水合肼 还原 合成 P-aminobenzyl alcohol,hydrazine hydrate,reduction,synthesis
分类号 TQ223.21 [化学工程—有机化工]
  • 相关文献

参考文献12

  • 1Bhatt R,Gong B,Hong F,et al.Preparation of 6-phenyl-[1,3,5] triazine-2,4-diamine derivatives and related compounds with lys0phosph atidic acid acyltransferases B (LPAA-B) inhibitory activity for use in the treatment of cancer[P].WO:2003 037346A1,2003-05-08.
  • 2Wang S,Advincula R.Synthesis and characterization of photo responsive all-azobenzene dendrimers:strategies for exponential growth of a macromolecular dye[J].Polym Mater Scie Eng,2001,85:611-612.
  • 3Chen J W,Qin C Q.Reduction of alkenes and aromatic nitro compounds with borohydride exchange resin(BER)cat-alyzed by transition metal compounds[J].React Polym,1992,16(31:287-295.
  • 4Graham B J,Curtis F C,Jude E M,et al.An image contrast agent selectively activated by prostate specific antigen[J].Bioorganic& Medicinal Chemistry,2006,14(2):418-425.
  • 5Menon V,Hsieh C T,Fitzpatrick P F.Substituted alcohols as mechanistic probes of alcohol oxidase[J].Bioorg Chem,1995.23(11:42-53.
  • 6Inagawa J.Biotin-derivatizing agent for labeling protein or DNA probes[P].jP:06092968,1994-04-05.
  • 7Hart B H,Jang D G.Montmorillonite-catalyzed reduction of nitrogenous with hydrazine[J].Tetrahedron Letters,1990,31(8)1181-11:82.
  • 8Mochida K,Kobayashi M Ando K.Biochemical manufacture of substituted benzyl alcohols from benzoic acids[P].JP:08056682.1996-03-05.Study On Synthesis of 4-Aminobenzyl A1coho1.
  • 9韦长梅,张荣,徐斌,王锦堂.苄醇对位硝化的研究[J].精细化工,2004,21(9):714-716. 被引量：2
  • 10张竹霞,吕荣文,张珂珂,高昆玉.水合肼还原芳硝基物的研究[J].精细化工,2001,18(4):239-242. 被引量：54

二级参考文献13

  • 1韦长梅,嵇鸣.苯乙腈定向硝化制备对硝基苯乙腈[J].精细化工,2001,18(4):234-235. 被引量：5
  • 2[2]Max Lauwiner, Paul Rys, Jorg Wissmann. Reduction of aromatic nitro compounds with hydrazine hydrate in the presence of an iron oxide hydrozide catalyst[J]. Applied Catalyais, 1998, A: General 172:141 -148.
  • 3[3]Max Iauwiner,Ronny Roth,Paul Rys. Reduction of aromatic nitro compounds with hydrazine hydrate in the presence of an iron oxide hydroxide catalyst[J]. Applied Catalysis, 1999,A: General 177:9-14.
  • 4David Firth,James Long. 4-Nitrobenzyl alcohol-an adaptable reagent for organic synthesis [ J ]. Speciality Chemicals, 1999, 19(1):16-18.
  • 5Caroline Joy Springer, Richard Marais. Preparation of prodrugs of protein tyrosine kinase inhibitors useful in treating cancer [ P ].PCT int Appl WO:9 502 420 A2,1995 -01 -26.
  • 6Masazumi Ito. 4-Nitrobenzylalcohol [ P ]. Jpn Kokai Tollyo Koho,JP:53 116 301. 1978 - 10 - 11.
  • 7Won S Park, Everett M. Marlett. Process for the preparation of alcohols or amines: tertiary-C3-8 -alkylamine alanes as selective reducing agents [ P ]. US :5 113 025,1992 - 05 - 12.
  • 8Jacqueline Boyer, Robert J P Corriu, Robert Perz, et al. Selective reduction of carbonyl compounds by heterogeneous catalysis on salt surfaces[ J]. J Chem Soc Chem Commun,1981, (3) :121 -122.
  • 9Enzo Santaniello,Carlo Farachi,Ada Manzocchi. Reduction of acid chlorides to hydroxy compounds by sodium borohydride adsorbed on alumina[ J ]. Synthesis, 1979, ( 11 ): 912.
  • 10Narasimhan S,Madhavan S,Ganeshwar Prasad K. A simple alkenecatalyzed reduction of aromatic esters to alcohols by zine borohydride[ J ]. Synthetic Communications, 1997,27 (3) :385 - 390.

共引文献53

化工设计通讯
2010年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部