肥大细胞在胃癌间质中的分布及其生物学

DISTRIBUTION OF MAST CELLLS IN THE STROMA OF GASTRIC ADENOCARCINOMA AND ITS BIOLOGICAL SIGNIFICNCE

目的研究胃腺癌间质中肥大细胞的分布及其生物学意义，探讨肿瘤间质中肥大细胞与淋巴细胞的相互关系。方法用组织化学的方法分别对46例胃腺癌的标本进行肥大细胞染色、计数，用秩和检验进行统计学分析。结果胃腺癌癌间质中肥大细胞的数量明显少于癌旁间质（P＜0．01）。癌间质内肥大细胞的数量与病理组织学类型有关，并与癌间质内淋巴细胞浸润的程度呈正相关。结论癌间质内肥大细胞数量少是肥大细胞脱颗粒的结果，是肥大细胞功能状态改变的一种形态学表现。提示肥大细胞通过脱颗粒释放介质参与抗肿瘤反应，并与间质内淋巴细胞具有协同作用。

To study the distribution of mast cells in tile stroma of gastric adenocarcinoma and itsrelationship with lymphocytes. Methods: Mast cells in 46 specimens of gastric adenocarcinoma stained with histochemistry were counted ho satistically analyzed by Rank-Sum test. Results: The number of the mast colls in the carcinoma stroma was significantly less than that less than that in paracarcinoma tissues (P<0.01 ). The number of mast cells in the carci carcinoma stroma was closely related to different histological types of carcinoma and had a positive correlation with lympho lymphocytes infiltration in carcinoma stroma. Conclusion: The scarcity of mast cells in the stroma of carcinoma is due to thedegranulation of the cells which is morphological expression of changes of mast cell function It suggests the degranulation of the mast cells and the lympbocytes infiltrate in stroma cooperated in anti-tumor reactions.