增敏化合物丁胱亚磺酰亚胺对Acc-2细胞的药物毒性

CYTOTOXICITY OF SENSITVE COMPOUND BSO ON ACC-2 CELLS

目的研究新型增敏化合物丁俄亚磺筑亚胶（buthioninesulfoximine，BSO）对ACC-2细胞药物毒性。方法采用克隆形成法研究在有氧状态和手氧状态下，BSO对ACC-2细胞的药物毒性，在实验中BSO的药物剂量分别是200、100、50、40、20μmol／L。结果在有氧和乏氧状态下，BSO对Acc-2细胞的半数抑制剂量分别为12μmol／L和80μmol／L。结论BSO的药物毒性较小，BSO在乏氧状态对Acc-2细胞的药物毒性强于有氧状态下对Acc-2细胞的药物毒性，

To study the cytotoxicity of BSO on ACC-2 cell. Methods: The cytoxicity of BSO(200 100,50,40,20μmol/L) on Acc-2 Cells was measured under aerobic and hypoxic condition by clonogenic assay.Results: The 50% inhibition doses(Id50) of BSO on Acc-2 cells were 120μmol/L, 80μmol/L, respectively underaerobic and hypoxic condition. Conclusion: The cytotokicity of BSO on Acc-2 cells under hypoxic condition is higherthan that under aerobic condihon.