含碘聚甲基丙烯酸酯类X光显影材料的制备

Preparation of Radiopaque Iodine-containing Polymethacrylate Biomaterials

由甲基丙烯酸正丁酯（BMA）与2-（2′-碘苯甲酰）-O-甲基丙烯酸乙酯（2-IEMA）自由基共聚制备了一种X光显影材料。1H NMR分析表明,该共聚物中2种结构单元之比与投料比吻合。GPC测得该共聚物的分子量随2-IEMA含量增加而降低。DSC分析表明,共聚物的玻璃化转变温度在22.3~28.0℃之间,与Fox方程计算值比较接近,而且随2-IEMA含量的增加而升高。TGA测得共聚物的分解温度为250℃,具有很好的热稳定性。力学性能测试结果表明,共聚物的拉伸强度随BMA含量的增加而增加,最大拉伸强度可达到7.46 MPa。X光显影性测试表明,该共聚物具有良好的显影性,显影效果随2-IEMA含量增加而增强。

A series of radiopaque copolymers were synthesized via the free radical polymerization of 2-（2′-iodobenzoyl）ethyl methacrylate（2-IEMA） with butyl methacrylate（BMA）.The compositions of 2-IEMA and BMA in the copolymers calculated by means of 1H NMR spectra were found to be in agreement with their feed molar ratios.The GPC analyses present that the M_n is decreased with the increase of 2-IEMA content.The DSC results imply that the T_g of the copolymers is between 22.3~28.0 ℃ which is in agreement with the result calculated by means of FOX equation,and the T_g of copolymers is increased with the increase of 2-IEMA content.The TGA measurements reveal that the thermal stability of the C—I bond endows the copolymers high thermal decomposition temperature.The mechanical testing shows that the tensile strength of the resulting copolymers is increased with the increase of BMA content with the maximum tensile strength reaching 7.46 MPa.These copolymers show the radiopacity as evidenced by X-ray fluoroscopy and their radiopacity is increased with the increase of 2-IEMA content.