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IL-32及其与结核病的相关性研究进展 被引量：1

Progress of research on IL-32 and its relationship with tuberculosis
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摘要 白介素-32是新近发现的一种前炎症反应细胞因子,有4种剪接变异体形式。研究发现IL-32与多种自身免疫性炎症性疾病和结核病的发生、发展有密切联系。本文对IL-32及其与结核病的相关性研究进展进行了综述。 Interleukin（IL）-32 is a recently identified proinflammatory cytokine;IL-32,the gene that codes for it,is one of the IL-18-inducible genes and exists in 4 variants.Interleukin-32 plays an important role in autoimmune and inflammatory diseases.IL-32 is highly expressed in inflamed synovial tissues from patients with rheumatoid arthritis,and the level of its expression correlates with the severity of arthritis and the expression of other cytokines,including TNF-α and interleukin-1.Recent studies have shown that IL-32 is closely related to the pathogenesis of tuberculosis.Summarized here is the progress of research on IL-32 and its relationship to tuberculosis.
作者 柳爱华 宣群 宝福凯
机构地区 昆明医学院生物化学与分子生物学教研室 昆明医学院微生物学与免疫学教研室
出处 《中国病原生物学杂志》 CSCD 2010年第3期215-217,共3页 Journal of Pathogen Biology
关键词 白细胞介素32 结核病 相关性 综述 Interleukin-32（IL-32） tuberculosis relationship review
分类号 R392.11 [医药卫生—免疫学]
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参考文献15

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二级参考文献41

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中国病原生物学杂志
2010年 第3期

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