NMR技术在体内药物分析中的应用

The Application of NMR Spectroscopy to Pharmaceutical Analysis in Vivo

ＮＭＲ技术的迅速发展，使其在药学领域中从新药的化学结构的预测扩展到对体液、组织中药物及其代谢物的分析。本文综述了近年发展的几种ＮＭＲ模式在体内药物分析中的应用。与其它分析方法相比，ＮＭＲ技术在体内药物分析中具有简便、无损伤、动态等特点。并且指出了该技术在应用中存在的问题和解决办法。

Compared with other analysis methods, NMR spectroscopy was characterized by simplicity, non invasion,and dynamic methods. This paper reviewed the application of NMR spectroscopy to pharmaceutical analysis in vivo. In addition, the main problems facing to the research and the prospects of the application were presented.