慢性HBV感染不同临床类型患者IL-2、IL-10水平的变化及其意义

Changes and Significances of IL-2 and IL-10 Lymphokines Levels in the Different Clinical Types of Patients with Chronic Hepatitis B Virus Infection

目的探讨慢性乙型肝炎病毒（hepatitis B virus,HBV）感染的不同临床类型患者白细胞介素2（IL-2）、白细胞介素10（IL-10）水平的变化及其意义。方法采用ELISA法检测91例慢性HBV感染患者[慢性重型乙型肝炎（慢重肝组,SH）18例,乙型肝炎肝硬化（肝硬化组,LC）25例,慢性乙型肝炎（慢乙肝组,CB）48例（其中重度17例、中度21例、轻度10例）]血清IL-2、IL-10的水平。应用SPSS 13.0 for window统计软件对3组慢性HBV感染不同临床类型患者IL-2、IL-10水平进行比较分析。结果慢重肝组血清IL-2、IL-10水平与肝硬化组比较,差异均无统计学意义（均P〉0.05）;慢重肝组与肝硬化组血清IL-2、IL-10的95%可信区间（95%CI）分别为：-36.88－33.72、-67.00-95.14。慢重肝组血清IL-2水平与慢乙肝组比较,差异无统计学意义（P〉0.05）;而血清IL-10水平与慢乙肝组比较,差异有统计学意义（P〈0.05）。慢重肝组与慢乙肝组血清IL-2、IL-10的95%CI分别为：-13.52-50.42、22.59-169.43。肝硬化组血清IL-2水平与慢乙肝组比较,差异无统计学意义（P〉0.05）;而血清IL-10水平与慢乙肝组比较,差异有统计学意义（P〈0.05）。肝硬化组与慢乙肝组血清IL-2、IL-10的95%CI分别为：-7.98-48.05、17.61-146.27。结论IL-2对慢性HBV感染的临床类型影响不大。而IL-10可能对慢性HBV感染的临床类型有影响,且血清IL-10水平的升高在炎症损伤反应中起到重要的作用。

Objective To explore the changes of the levels of IL-2 and IL-10 in the different clinical types of patients with chronic hepatitis B virus（HBV） infection and to evaluate their significance.Methods The levels of IL-2 and IL-10 lymphokines in the sera of 91 different clinical types of patients with chronic HBV infection[the chronic severe hepatitis B（chronic severe hepatitis group,SH）18 cases,the hepatic cirrhosis（the cirrhosis group,LC）25 cases,the chronic hepatitis B（the chronic hepatitis B group,CB）48 cases（heavy degree hepatitis 17 cases,moderate degree hepatitis 21 cases,mild degree hepatitis 10 cases）were tested by enzyme liked immunosorbent assay（ELISA） respectively,and the data was analyzed with SPSS13.0 for window.Results There was no significant difference（all P〉0.05） in comparison of the IL-2 and IL-10 lymphokine level between the severe hepatitis B（SH） and the hepatic cirrhosis（LC） groups.And the 95% confidence interval were-36.88-33.72,-67.00-95.14 respectively in comparison of the IL-2 and IL-10 lymphokine level between the severe hepatitis B（SH）and the hepatic cirrhosis（LC） groups.IL-2 level in SH compared to CB had no significant difference（P〉0.05）,but IL-10 level in SH compared to CB had a significant difference（P〈0.05）;The 95% confidence interval of IL-2 and IL-10 in SH and CB were-13.52-50.42、22.59-169.43 respectively;there was no significant difference（P〉0.05） in comparison of IL-2 lymphokine level between the LC and the CB groups,but significance of IL-10 lymphokine level was seen（P〈0.05）;The 95% confidence interval of IL-2 and IL-10 in SH and CB were-7.98-48.05,17.61-146.27 respectively.ConclusionIL-2 lymphokine might play no important role in the different clinical types of chronic hepatitis B virus infection.IL-10 lymphokine might play a part in the development of different clinical types of chronic hepatitis B virus infection.The higher serum IL-10 level might have an fairly important role in the inflammatory response to injury.