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曲张大隐静脉管壁T、B淋巴细胞和肥大细胞浸润的定量研究 被引量：1

Quantitative Study of T、B Lymphocytes and Mast Cells in the Wall of Varicose Great Saphenous Veins
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摘要 目的探讨T、B淋巴细胞和肥大细胞在曲张大隐静脉(varicose great saphenous vein,VGSV)血管壁中的浸润变化。方法收集不同临床分期的曲张大隐静脉主干标本,采用免疫组织化学染色和甲苯胺蓝特殊染色分别检测9例曲张静脉伴有皮肤营养改变(皮肤改变组)、10例单纯曲张静脉(曲张组)和9例正常静脉组织(对照组)CD45RO、CD20及肥大细胞表达。结果T淋巴细胞、B淋巴细胞、肥大细胞计数在皮肤改变组为0.13±0.05/HP、0.05±0.05/HP、0.26±0.10/HP,曲张组为0.08±0.05/HP、0.07±0.06/HP、0.18±0.10/HP,对照组为0.13±0.06/HP、0.05±0.04/HP、0.26±0.17/HP,3组之间比较差异无显著性意义(均P>0.05)。结论下肢曲张静脉病期的变化与T、B淋巴细胞和肥大细胞血管壁的浸润无相关性。 Objective To investigate the infiltrating variation of T and B lymphocytes and mast cells in the wall of varicose great saphenous vein.Methods Collecting the bole specimens of varicose great saphenous vein in different clinical stages.There were 9 cases of varicose veins with skin changes in nutrition（skin changes group）,10 cases of simple varicose veins（varicose vein group） and 9 cases of normal venous tissue（control group）.The expression of CD45RO,CD20 and mast cells with immunohistochemical staining and toluidine blue staining were detected for all cases,respectively.Results There was no significant difference of quantities for T lymphocytes,B lymphocytes,mast cells between skin changes group（0.13±0.05/HP,0.05±0.05/HP,0.26±0.10/HP）,varicose vein group（0.08±0.05/HP,0.07±0.06/HP,0.18±0.10/HP）,control group（0.13±0.06/HP,0.05±0.04/HP,0.26±0.17/HP）（all P〉0.05）.Conclusion There is no correlation between the stage changes of varicose vein in the lower limbs and the infiltration in the vessel wall of T and B lymphocytes and mast cells.
作者 王国华 褚海波 王涛 徐永波 郭文君
机构地区 潍坊医学院研究生部 中国人民解放军第 中国人民解放军第 潍坊医学院病理教研室
出处 《实用临床医学（江西）》 CAS 2010年第2期12-15,F0003,共5页 Practical Clinical Medicine
关键词 静脉曲张 T淋巴细胞 B淋巴细胞 肥大细胞 varicose vein T lymphocyte B lymphocyte mast cell
分类号 R654.4 [医药卫生—外科学]
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参考文献12

  • 1张培华,将米尔.华东四省一市周围血管病调查研究[J].普外临床,1993,8(3):162-164. 被引量：106
  • 2Gibbons G H,Dzau V J.The emerging concept of vascular remodelling[J].N Engl J Med,1994,330:1431-1438.
  • 3Yamada T,Tomita S,Mori M,et al.Increased mast cell in filtration in varicose veins of the lower limbs:a possible role in the development of varices[J].Surgery,1996,119(5):494-497.
  • 4龚非力.医学免疫学[M].2版.北京:科学出版社,2006:144-153.
  • 5Michel R B.Leukocyte involvement in the signs and symptoms of chronic venous disease:perspectives for therapy[J].Clinical Hemorheology and Microcirculation,2007,37:277-290.
  • 6Takase S,Bergan J J,Schmid Schonbein G W.Expression of adhesion molecules and cytokines on saphenous veins in chronic venous insufficiency[J].Ann Vasc Surg,2000,21:427-435.
  • 7Sayer G L,Smith P D.Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins[J].Eur J Vasc Endovasc Surg,2004,28(11):479-483.
  • 8Yamada T,Yamamoto H,Ogawa A,et al.Ulrastructural demonstration of mast cells in varicose veins of lower limbs:presence of mast cell-mediated mechanism[J].J Cardiovasc Surg,1997,38(5):443-446.
  • 9Haviarová Z,Weismann P,Pavlíková D,et al.Mast cell infiltration in the wall of varicose veins[J].Acta Histochem,2002,104(4):357-360.
  • 10Kakkos S K,Zolota V G,Peristeropoulou P,et al.Increased mast cell infiltration in familial varicose veins:Pathogenetic implications?[J].International Angiology,2003,22(1):43-48.

共引文献106

同被引文献19

  • 1Bergan JJ,Schmid-Schonbein GW,Smith PDC,et al.Chronic venous disease[J].N Engl J Med,2006,355(5):488-498.
  • 2Gibbons GH,Dzau VJ.The emerging concept of vascular remodeling[J].N Engl J Med,1994,330(20):1431-1438.
  • 3Wakefield TW,Myers DD,Henke PK.Mechanisms of venous thrombosis and resolution[J].Arteriosclero Thromb Vasc Biol,2008,28(3):387-391.
  • 4Nicolaides AN.Chronic venous disease and the leukocyte-endothelium interaction:from symptoms to ulceration[J].Angiology,2001,52(suppl 1):27-34.
  • 5Borish L,Joseph BZ.Inflammation and the allergic response[J].Med Clin North Am,1992,76(4):765-787.
  • 6Mekori YA,Metcalfe DD.Mast cell-T cell interactions[J].J Allergy Clin Immunol,1999,104(3):517-523.
  • 7Yamada T,Yamamoto H,Ogawa A,et al.Ultrastructural demonstration of mast cells in varicose veins of lower limbs:presence of mast cell-mediated mechanism[J].Cardiovascular Surgery,1997,38(5):443-446.
  • 8Wali MA,Eid RA.Intimal changes in varicose veins:an ultrastructural study[J].Journal of Smooth Muscle Research,2002,38(3):63-74.
  • 9Kroegel C,Reiesig A.Principle mechanisms underlying venous thromboembolism:epidemiology,risk factors.Pathophysiology and Pathogenesis[J].Respiration,2003,70(1):7-30.
  • 10Nosaka M,Ishida Y,Kimura A,et al.Time-dependent appearance of intrathrombus neutrophils and maerophages in a stasis-induced deep vein thrombosis model and its application to thrombns age determination[J].Int J Legal Med,2009,123(3):235-240.

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实用临床医学（江西）
2010年 第2期

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