尼莫地平联合艾地苯醌治疗血管性痴呆的临床疗效

Clinical effect of nimodipine combined with idebenone on vascular dementia

目的:探讨尼莫地平防治脑卒中后血管性痴呆(VaD)的临床疗效。方法:将42例脑卒中患者随机分为:受试组和对照组各21例,对两组原发病均遵照神经内科诊疗指南进行常规治疗,受试组另予尼莫地平片(30mg,口服,3/日)+艾地苯醌片(30mg,口服,3/日),对照组单纯尼莫地平(30mg,口服,3/日),连续给药3个月并进行智能测定,以观察两组治疗后VaD认知功能障碍的改善情况。应用修订简易精神状态量表(MMSE)、临床痴呆程度量表(CDR)和Barthe指数评定量表(BI)评价疗效。结果:与对照组比较受试组可显著提高MMSE、CDR和BI评分,差异有统计学意义(P<0.05)。结论:艾地苯醌联合尼莫地平治疗VaD疗效优于单纯口服尼莫地平。

Objective： To explore the curative effect of nimodipine combined with idebenone on post- stroke vascular dementia （VaD）. Methods： Forty-two （n =42） patients with stroke were enrolled who were randomly divided into a treatment group（n =21） and a control group（ n = 21）. In each group the primary disease were routinely treated with guidelines of neurology. The treatment group took nimodipine and idebenone tablets, and control group took nimedipine tablets in which all tablets were given three times a day for 3 months. MMSE, CDR and BI score method were used to estimate the therapeutic effect. Results： Compared with the contrel group, the MMSE, CDR and BI scores were increased significantly in the treatment group （P 〈 0.05）. Conclusion： Nimodipine combined with idebenone were superior to isolated treatment with nimodipine.