3300例甲型H1N1流感疫苗接种者的安全性观察

Safety Observation of Influenza A H1N1 Influenza Vaccine Vaccinations in 3300 Medical Workers

目的观察分析接种国产甲型H1N1流感疫苗者的安全性。方法按照集中自愿的原则,对我院3300例医务工作者接种上海生物制品有限公司生产、批号为200909012的甲型H1N1流感疫苗,并观察其接种后不良反应,包括接种半小时内、3天内和1周内不良反应例数及表现症状。结果3300例接种H1N1流感疫苗者中,有自觉不适或全身不良反应者占1.18%(39/3300)。接种疫苗后半小时内出现不适者占0.15%(5/3300);接种疫苗后1～3天后出现不适者占0.70%(23/3300);接种疫苗后3天至1周内出现不适者占0.33%(11/3300)。无严重不良反应发生。结论国产甲型H1N1流感疫苗不良反应发生较少,其安全性可靠,是目前预防甲型H1N1较经济有效的手段之一。

Objective To investigate safety of influenza A H1N1 vaccine vaccinations. Methods A total of 3 300 medical workers were vaccinated by batch of 200909012 influenza A H1N1 vaccine produced by Shanghai Biological Products Corporation Limited according to the principle of voluntary and concentration. The adverse reactions were observed within half an hour, three days and a week after vaccinations, respectively. Results The inoculators with local or systemic reaction reached 1.18% （39/3 300）. There were 0.15% （5/3 300） of the inoculators with adverse reaction within half an hour; 0.70% （23/3 300） within 1 to 3 days after vaccination; and 0.33% （11/3 300） within 3 days to 1 week after vaccination. No severe adverse events were found. Conclusion Influenza A H1N1 vaccine vaccinations is an economic and effective way of influenza A H1N1 prevention with mild reactions.