血型血清学技术对新生儿溶血病的产前诊断价值

Diagnostic value of blood serum technique for newborn babies with HDN

目的通过对2009年5月1日至6月29日所有在陕西省人民医院放免中心进行新生儿溶血病(HDN)检测的289对产前夫妇的检测结果分析,为临床的诊断、预防和治疗提供指导。方法用玻片法检测ABO(RH)血型,用试管法对血清倍比稀释至第8管检测特异性抗体效价。结果效价大于或等于64的95例,效价大于或等于128的56例,效价大于或等于256的6例。结论孕妇为O型血,丈夫为非O型血患者的测定结果阳性率最高达54.1%。与相关文献报道一致,应引起重视,是临床早期诊断和预防性治疗的重点关注对象。

Objective Through the analysis of the test results of HDN of 289 couples conducted at the Radio Immunity Center of Shangxi People＇s Hospital from 1 May to 29 June of 2009, the study intends to provide guidance to the clinical diagnosis, prevention and medical treatment. Methods The type of ABO（RH） of the blood serum is tested by the agglutination test method while the blood serum of the subjects are diluted to the 8th tube by applying the test tube method in accordance with the law of multiple proportion. Results We found 95 cases of titer （≥64）, 56 cases of titer ≥1280, and 6 cases of titer ≥256）. Conclusion The positive rate of the pregnate women with type O blood whose husbands with non O type is the most high, reaching to 54,1 %, which is in conformity with the concerned reports of Literature. Thus attention should especially be paid to those patients mentioned above, and at the same time, they should be regarded as the key patients in clinical diagnose and preventive treatment.