急性肺损伤和急性呼吸窘迫综合征的预后评估指标

Prognostic indicators of acute lung injury and acute respiratory digress syndrome

急性肺损伤、急性呼吸窘迫时机体发生一系列的病理生理变化，研究者通过对相关临床、生化指标进行研究发现其中一些指标与预后密切相关。临床指标包括年龄、病因、器官功能不全、免疫抑制等。生化指标包括心功能指标氨基末端脑钠肽前体、心肌酶；凝血纤溶相关指标蛋白C；肺表面活性物质；氧化应激产物：一氧化氮、血管假性血友病因子、炎症因子等。利用这些指标可以判断疾病进展，为指导后续治疗提供依据。

A series of pathophysiological changes occur when acute lung injury （ALI） or acute respiratory distress （ARDS） happens. Studies have shown that some of the clinical and biochemical indicators are closely related with the prognosis of ALl or ARDS. Clinical indicators including age,etiological factor,organ dysfunction, immune suppression, etc. Biochemical indicators include cardiac function-related indicator the amino-terminal pro-brain natriuretic peptide,myocardial enzyme;coagulation and fibrinolysis related indi- cator protein C; pulmonary surfactant; products of oxidative stress nitric oxide, von Willebrand factor ,inflammatory factors,etc. So it is available to make use of relevant indicators to determine the evolution of the disease and guide follow-up therapy.