美托洛尔治疗慢性心力衰竭的临床疗效观察

Observation of clinical effect of Metoprolol in the treatment of chronic heart failure

目的:评价美托洛尔对慢性心力衰竭患者心功能及血浆脑钠肽(BNP)的影响。方法:将70例慢性心力衰竭患者随机分为对照组35例和治疗组35例,对照组给予地高辛、利尿剂、血管紧张素转换酶抑制剂或血管紧张素Ⅱ受体拮抗剂治疗,治疗组在此基础上加用美托洛尔。观察治疗前及治疗结束后患者的心功能及BNP变化。结果:与治疗前相比,治疗组的左心室短轴缩短率(LVFS)、左心室射血分数(LVEF)、BNP值明显改善;与对照组比较,治疗组的临床疗效显效率和总有效率均较高,且LVFS、LVEF、BNP值差异显著。结论:美托洛尔能改善慢性心力衰竭患者的心功能,且安全有效。

Objective：To evaluate the effects of Metoprolol on the heart function and brain natriuretic peptide in chronic heart failure patients. Methods：70 patients with chronic heart failure were divided into control group （35 patients） and therapy group （35 patients）. The control group patients were given basic treatment with Digoxin,Diuretics,Angiotensin converting enzyme inhibitor （ACEI） or Angiotensin II receptor blocker（ARB）; the therapy group were given Metoprolol in ad-dition to the basic treatment. Heart function and BNP level in chronic heart failure patients was observed before and after treatment. Results：After treatment,BNP level,left ventricular ejection fraction（LVEF） and left ventricular diameter （LVFS） were obviously improved for therapy group. Compared with control group,the excellence rate and total effective rate increased significantly,BNP level decreased and LVEF and LVFS increased in therapy group. Conclusion：Metoprolol can be used improve the heart function in chronic heart failure patients,and it is effective and safe.