隔山逍遥方配合针刺治疗腹泻型肠易激综合征疗效观察

Clinical observation of "Geshan Xiaoyao Decoction" plus acupuncture in treating diarrhea-predominant irritable bowel syndrome

目的观察隔山逍遥方配合针刺疗法治疗腹泻型肠易激综合征的临床疗效。方法采用随机数字表法将173例受试对象分为4组:I组(79例)予隔山逍遥方配合针刺,Ⅱ组(31例)予丽珠肠乐,Ⅲ组(32例)单纯口服隔山逍遥方,IV组(31例)单纯予针刺治疗(方法同治疗组针刺);各组疗程均为4周,观察临床疗效及治疗结束6个月后的复发率。结果I组总有效率为88.61%,Ⅱ组为67.74%,Ⅲ组为78.13%,IV组为70.97%;I组疗效与各对照组比较,差异均有统计学意义(P<0.05)。I组治疗前后各项症状积分差异均有统计学意义(P<0.05),各对照组治疗前后部分症状积分差异有统计学意义(P<0.05)。I组与对照组(Ⅱ-IV组)比较,各症状疗效均优于Ⅱ组,对肠鸣、神疲懒言疗效优于Ⅲ组,对大便泄泻、食欲不振、倦怠乏力疗效优于IV组,差异均有统计学意义(P<0.05)。6个月后I组复发率为22.86%,Ⅱ组为61.11%,III组为55.00%,IV组为63.16%;I组与各对照组比较,差异均有统计学意义(P<0.05)。结论隔山逍遥方配合针刺治疗腹泻型肠易激综合征有较好的临床疗效,且复发率低。

Objective To observe the clinical efficacy of ＂Geshan Xiaoyao Decoction＂ plus acupuncture in treating diarrhea-predominant irritable bowel syndrome. Methods Total 173 subjects were randomized into four groups：group A in which 79 cases were treated with ＂Geshan Xiaoyao Decoction＂ plus acupuncture,group B in which 31 cases were treated with bifidobacteria capsule,group C in which 32 cases were treated with ＂Geshan Xiaoyao Decoction＂ and group D in which 31 cases were treated with acupuncture,with a course of four weeks. The clinical efficacy and six-month relaspe rate were observed. Results The total effective rate was 88.61% in group A,67.74% in group B,78.13% in group C and 70.97% in group D,with a higher rate in group A than in groups B,C and D（P0.05）; the scores of clinical symptoms were all reduced in the four groups（P0.05）; the six-month relapse rate was 22.86% in group A,61.11% in group B,55.00% in group C and 63.16% in group D,with a lower rate in group A than in the other three groups（P0.05）. Conclusion ＂Geshan Xiaoyao Decoction＂ plus acupuncture is quite effective for diarrhea-predominant irritable bowel syndrome,with low relapse.