血清总胆汁酸、胆固醇、AST/ALT比值与肝硬化Child-Pugh分级的关系

Relationships of serum total bile acids,cholesterol and AST/ALT ratio with the Child-Pugh classification in cirrhosis

目的:探讨肝炎后肝硬化患者不同Child-Pugh分级与血清总胆汁酸(TBA)、胆固醇(CHO)、AST/ALT比值的相互关系。方法:选取临床诊断为肝炎后肝硬化患者76例,按Child-Pugh评分进行分级(A、B、C级);对照组48例为健康体检者,并检测血清TBA、CHO、AST/ALT比值。结果:肝硬化组与对照组比较,血清TBA升高,血清CHO降低,AST/ALT比值升高,差异有高度统计学意义(P<0.01)。肝硬化患者Child-Pugh分级A、B、C级之间比较,差异有高度统计学意义(P<0.01)。结论:肝硬化患者血清TBA、CHO、AST/ALT比值联合检测有助于肝硬化患者进行肝功能分级,并有助于评估肝功能受损程度。

Objective：To study the possible relationships of serum total bile acids （TBA）,cholesterol （CHO） and AST/ALT ratio to different Child-Pugh classifications in patients with HBV-related cirrhosis. Methods：Selected clinically diagnosed 76 cases of patients with liver cirrhosis according to Child-Pugh score for classification （grade A,B and C） as the cirrhosis group,48 cases of healthy persons were served as the control group,the serum TBA,CHO and AST/ALT ratio of the two groups were detected. Results：Compared with the control group,the serum TBA of cirrhosis group increased,serum CHO reduced,AST/ALT ratio increased,they showed significant difference （P〈0.01）. Patients with liver cirrhosis according to Child-Pugh classification had significant difference among grade A,B and C （P〈0.01）. Conclusion：Patients with liver cirrhosis with serum TBA,CHO and AST/ALT ratio of the joint detection helps classification of liver function in patients with liver cirrhosis,and helps to assess the degree of liver dysfunction.