七氟醚对肺癌患者围术期TNF-α的影响

Effect of sevoflurane on the serum concentration of TNF-α during the periperative period in lung carcinoma patients

目的:观察七氟醚对肺癌患者围术期血清中肿瘤坏死因子α(TNF-α)的影响。方法:选择30例Ⅰ～Ⅱ期肺癌择期行左侧开胸肺叶切除手术患者,ASAⅠ～Ⅱ级,随机分为芬太尼组(C组)和七氟醚组(S组)。分别于麻醉诱导前1min(T1),单肺通气40min(T2)、90min(T3)和120min(T4)时取外周静脉血样测TNF-α浓度。结果:单肺通气后两组TNF-α水平均较单肺通气前显著升高(P<0.05)。单肺通气(OLV)后T3、T4时刻TNF-α水平C组显著高于S组(P<0.05)。结论:七氟醚可降低肺癌患者血清TNF-α的浓度,减轻围术期的全身炎症反应。

Objective：To study the effect of sevoflurane on the alternation of serum concentration of TNF-α during the periperative period in patients undergoing pulmonary lobectomy of left-thoracis surgery. Methods：30 cases of Ⅰ-Ⅱ lung carcinoma patients,ASA Ⅰ-Ⅱ,scheduled for elective pulmonary lobectomy of left-thoracis surgery were divided into fentanyl groups （C） and sevoflurane groups （S）. The peripheral vein blood samples were collected 1 minute before anesthesia induction 60,90,120 minutes after one-lung ventilation （OLV） for the detection of TNF-α. Results：The concentration of TNF-α was significantly increaded after OLV than that before OLV in two groups （P〈0.05）; the concentration of TNF-α was significantly increaded in groups C than that in group S after OLV （P〈0.05）. Conclusion：During the periperative period,sevoflurane could reduce the serum concentration of TNF-α in lung carcinoma patients,result in alleviation of systemic inflammatory response.