TIMP-1在肝纤维化形成发展过程中的影响研究

TIMP-1 in the Process of the Formation and Development of Hepatic Fibrosis Influence

肝纤维化是对慢性肝损伤的一种修复反应,其实质是Ⅰ、Ⅲ型胶原为主的细胞外基质(extracellular matrix,ECM)合成与降解失衡,在肝内过度沉积而形成的病理性疾病。而基质金属蛋白酶(matrix metallo proteinas-es,MMPs)及其抑制因子(tissue inhibitor ofmetallo proteinases,TIMPs)是调节ECM降解的主要酶系。TIMP-1是肝脏中仅有的两种基质金属蛋白酶组织抑制因子之一,被认为是肝纤维化发生过程中的重要因素。

Fibrosis is a chronic liver damage repair response, its essence is I , Ⅲ collagen type of extracellular matrix （ECM） extracellular matrix, synthesis and degradation of imbalance in the liver, sedimentary and formation of excessive sex disease. And matrix metalloproteinases matrix metalloproteinases MMPs, （the） and inhibitory factor （ ofmetallopro- teinases inhibitor, TIMPs） tissue is to adjust the main enzymes ECM degradation. TIMP - 1 is the only two kinds of liv- er matrix metalloproteinases organization inhibitory factor, is considered one of the process of hepatic fibrosis is an impor- tant factor.