慢性焦虑应激大鼠行为学的变化及高架十字迷宫的测评

The Changes in Behaviour of Rats with Chronic Stress-induced Anxiety and Behavioural Evaluation of The Elevated Plus-maze Test System

目的:以慢性焦虑应激大鼠为载体,探讨其焦虑状态及行为学的变化,旨在探索能较好模拟广泛性焦虑障碍的动物模型。方法:采用慢性情绪应激的方法建立焦虑大鼠模型,以国际公认的高架十字迷宫试验对其行为学进行评价。结果:应激后大鼠处于易激惹的状态,表现出频繁的修饰和攻击行为,经高架十字迷宫测试发现大鼠较少进入并停留于开放臂中,倾向于探究封闭臂,且在封闭臂的停留时间延长。结论:不确定性空瓶刺激作为一种慢性心理应激模型,从病因学上较好模拟了广泛性焦虑障碍的发病状态和行为学表现。

Objective ： To study the changes in behaviour of rats model with chronic stress - induced anxiety and to ex- plorc a appropriate animal model for GAD. Methods ： Rats model was established by using chronic emotional stress - in- duced anxiety method, then researchers observed behavioural changes of model rats and evaluation of elevated plus - maze test system. Results ： Rats rcsceiving emotional stress was in a state of great agitation, who manifested obvious grooming and attacking behaviour. Fewer rats entered and remained in the open ann, and tended to explore and stay in the closed arm. Conclusion ：Unpredictable bottle stimulation as a methd of chronic emotional stress better simulated the incidence and manifestation of generalized anxiety disorder from etiology.