止痛消结丸治疗大鼠乳腺增生病的实验研究

Pain-relieving Disappears Ties the Pill to Treat the Experimental Study Which the Big Mouse Mammary Gland increases Falls Ill

目的:通过观察止痛消结丸对乳腺增生病大鼠血液流变性及乳腺组织病理的改变,探讨止痛消结丸治疗乳腺增生病的机理。方法:选用SPF级雌性Wistar大鼠70只,随机分为空白对照组、模型对照组、模型证实组、止痛消结丸大、中、小剂量组、阳性对照乳癖消片组,采用苯甲酸雌二醇和黄体酮建立乳腺增生动物模型,予以相应药物治疗,空白对照组、模型对照组不用药。观察乳腺增生病大鼠血液流变性改变及乳腺组织病理变化。结果:模型组大鼠血液呈高黏、凝、聚状态,各用药组血液流变性指标大部分接近或低于正常水平,其中以止痛消结丸大剂量组作用尤为显著(P<0.01)。结论:止痛消结丸可改变乳腺增生病大鼠的血液流变性,改善乳房的微循环,是其治疗和预防乳腺增生病的机理之一。

Objective ：Disappears through the observation pain- relieving ties the pill to increase to the mammary gland falls ill the big mouse blood rheological property and the mammary gland organization pathology change, the discus- sion pain -relieving disappears ties the mechanism which the pill treatment mammary gland increases falls ill. Methods： Selects SPF level female Wistar big mouse 70, divides into the blank control group, the model control group, the model to confirm that stochastically the group, the pain - relieving disappear tie the pill large, medium and small monitoring team, the masculine gender to compare the young hobby to disappear the piece group, uses the benzoic acid estradiol and the progestin establishment mammary gland proliferation animal model, gives the corresponding pharmacological treat- ment, the blank control group, the model control group does not apply drugs. Observes the mammary gland to increase falls ill the big mouse blood rheological property change and the mammary gland organization pathological change. Results ： The model group big mouse blood assumes Gao Zhan, to congeal, to gather the condition, each medication group blood rheological propertyless target majority of close or is lower than the normal level, stops pain disappears ties the pill big monitoring team function to be especially remarkable （ P 〈 O. O1 ） Conclusion： The pain -relieving disappears ties the pill to be possible to change the mammary gland to increase falls ill the big mouse~ blood theological property, improves breast＇s microcycle, is one which of mechanisms its treatment and the prevention mammary gland increase fall ill