摘要
白细胞介素-6(interleukin-6,IL-6)是一种多效性细胞因子,在很多自身免疫性疾病的炎症反应和免疫应答中有重要作用。IL-6依赖与其可溶性白细胞介素-6受体α(soluble Interleukin-6 receptor,sIL-6Rα)或膜型受体结合,并通过gp130完成细胞内信号传导以发挥其一系列生物学活性。在许多自身免疫性疾病中都发现有IL-6和sIL-6Rα升高,因此阻断IL-6的作用可能对改善某些自身免疫性疾病有重要作用。目前,IL-6阻滞剂的作用已经在动物实验及临床试验得到证实。tocilizumab作为第一个人源化IL-6受体单抗,对治疗类风湿关节炎等自身免疫性疾病效果显著。
Interleukin-6 （ IL-6） is a pleiotropi c cytokine involved in both the initiation and maintenance of inflammatory and immunologic responses in certain autoimmune diseases. IL-6 binds to its soluble and membrane-bound receptors, and interacts with gp130 transduces intracellular signals that mediate gene activation and a wide range of biologic activities. The levels of both IL-6 and sIL-6Rα are elevated to various degrees in many autoimmune diseases. IL-6 blockade has been shown to be beneficial both in experimental models and in human diseases, and inhibition of IL-6 signaling with molecules such as tocilizumab could prevent or reverse some of the complications typically associated with autoimmune diseases, such as rheumatoid arthritis.
出处
《中华临床免疫和变态反应杂志》
2010年第1期55-60,共6页
Chinese Journal of Allergy & Clinical Immunology
