摘要
聚酮化合物Monacolin K是一种高效的降胆固醇药物,由红曲菌和土曲霉次级代谢产生。早期以土曲霉为研究对象,揭示了相关的生物合成基因簇及其功能。近年来的研究发现,虽然Monacolin K在这2种产生菌中的生物合成途径完全相同,但红曲菌中Monacolin K相关的生物合成基因和土曲霉并不完全一致。对红曲菌功能基因组的深入研究,以及相应遗传转化体系的建立与完善,对进一步开发生产更多的聚酮化合物必将出现新的契机。
Monacolin K, one of potent cholesterol-lowering polyketide compounds, could be produced by Monascus spp and Aspergillus terreus. In the early researches, Monacolin K biosynthetic gene clusters and its functions had been revealed in A. terreus. Although the biosynthetic pathway of Monacolin K in Monascus spp has been found as same as that in A. terreus, the biosynthetic genes were not so identical in the two producers. With the further study on Monascus functional genomics, as well as the establishment and improvement of the corresponding genetic transformation system, it is believed that more potent cholesterol- lowering polyketide by Monascus could emerge.
出处
《中国酿造》
CAS
北大核心
2010年第4期5-8,共4页
China Brewing
