稻花香活力型酒对雌雄大鼠体重变化及肝脏作用的比较

Comparison of the changes of body weight and liver toxic of riceflower-perfume energy liquor to male and female rates

观察稻花香活力型酒(RPEL)对雌雄大鼠体重变化、肝脏脏器系数、ALT和AKP及肝脏病理切片的差异。体重相当的Wister大鼠随机分为雌雄高、中、低剂量组,雌8雄7,高剂量组3.44mL/kg;中剂量组1.72mL/kg;低剂量组0.86mL/kg。每日实验大鼠经口给稻花香活力型酒1次,连续45d,每周测体重1次,末次给药后称重,取血测定ALT和AKP,称肝重;计算肝脏脏器系数;作肝脏病理组织学检查。稻花香活力型酒对雌雄对应剂量组体重变化和AKP及病理差异有显著意义。肝脏脏器系数雌雄对应组差异无显著意义。稻花香活力型酒对雌雄大鼠作用不同。

The changes of body weight, liver organ index, ALT and AKP, pathological examination of lung of Riceflower-perfume energy liquor （RPEL） to male and female rates were investigated in this paper. Sixty wister rats were randomly divided into three experiment groups and one control group （8 females and 7 males in each group）. The rats from experiment groups were orally administrated with RPEL at 9：00 AM every morning for 45 days, with a high dosage （3.44 ml/kg）, medium dosage （1.72 ml/kg）, low dosage （0.86 ml/kg） respectively. Meanwhile, the changes of body weight were measured every week. Experiments for liver organ index, ALT and AKP, pathological examination of lung were carried out after the last consumption of the liquor. The changes of body weight, AKP and pathological examination of lung showed significant differences between the male rats and the female rats. RPEL has significant differences between the male rats and female rats.