2,4,6-三氧-1,3,5,2-三氮磷杂环己烷衍生物的合成及其抗肿瘤活性(英文)

Synthesis of Novel Derivatives of 2,4,6 Trioxo 1,3,5,2 triazaphosphorine and Their Antitumor Activities

利用Ｎ，Ｎ－二（２－氯乙基）氨基磷酰二异氰酸酯和胺的加成反应，合成了２，４，６－三氧－１，３，５，２－三氮磷杂环己烷衍生物，它们的结构经１ＨＮＭＲ，ＩＲ和元素分析所证实。初步生物活性测试结果表明，部分化合物具有一定的抗肿瘤活性。

Six new derivatives of 2,4,6 trioxo 1,3,5,2 triazaphosphorine have been synthesized by the reactions of N,N bis(2 chloroethyl)aminophosphoryldiisocyanate with amines. The structures of the products were confirmed by 1H NMR,IR and elemental analysis.The preliminary bioassay indicated that some of them had antitumor activities.