艾司西酞普兰治疗惊恐障碍对照研究

Study of escitalopram and sertraline in treatment of panic disorder

目的:研究艾司西酞普兰和舍曲林治疗惊恐障碍的有效性和安全性。方法:65例惊恐障碍患者随机分入艾司西酞普兰组与舍曲林组治疗10周,在治疗前和治疗期间隔周测定惊恐症状评定量表(PASS)、临床总体印象-严重性(CGI-SI)、患者总体评价(PGE),汉密尔顿焦虑量表(HAMA)及每周发作次数,以治疗中出现的症状量表(TESS)评定不良反应。结果:艾司西酞普兰组有效率为96.8%,舍曲林组为93.3%,二药相近。两组患者在治疗10周PASS、CGI-SI、PGE、HAMA的减分率差异无显著性。艾司西酞普兰组的起效时间快于舍曲林组,差异具有显著性(P<0.01)。两组患者均有良好的耐受性。结论:艾司西酞普兰是一种起效快、疗效好、安全性高的治疗惊恐障碍的药物。

Objective：To evaluate the efficacy and safety of eseitalopram and sertraline in the treatment of patients with panic disorder. Method：Sixty-five patients with panic disorder were randomly assigned to escitalopram grnup or sertraline group for 10 weeks. The panic symptom scale（PASS） , clinic global impression-severity of illness（ CGI-SI ） ,patients general evaluate（PGE） and Hamihon anxiety scale（ HAMA ） were used to evaluate the efficacy,and the treatment emergent symptom scale（TESS） were used to evaluate the side effects. Results：After 10 weeks treatment,the mean scores of PASS, CGI-SI, PGE and HAMA reduced in both groups . The rates of efficacy of eseitalopram and sertraline were 96.77% and 93.33% respectively,and there were no statistically significant differences in the efficacy between two groups. But it took effect more quickly in eseilalopram group than in sertraline group（ P 〈 0.0f ）. Patients of both groups had good tolerance. Conclusion ： Escitalupram is an effective and well-tolerated drug in the treatment of panic disorder,and takes effect quickly.